Rahimah Othman
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Preferred name
Rahimah Othman
Official Name
Rahimah, Othman
Alternative Name
Othman, Rahimah
Othman, R.
Main Affiliation
Scopus Author ID
24348849600
Researcher ID
DWI-3419-2022

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  • Publication
    Smart self-assembled polymeric-MMT/Moringa Oleifera L. particles by solvent replacement method
    ( 2024-10)
    Rahimah Othman
    ;
    Koh Qi Sheng
    ;
    Mohd Irfan Hatim Mohamed Dzahir
    ;
    Monisha Devi
    ;
    Siti Pauliena Mohd Bohari
    Obesity, stemming from metabolic syndrome and energy imbalance, is a common health concern characterized by excess energy consumption and fat buildup. Moringa Oleifera L. (MO), known for its anti-obesity properties, is extracted via Soxhlet extraction. MO is extracted using the Soxhlet extraction method. To evaluate the antioxidant properties of MO powder, several analyses were conducted, including the assessment of total phenolic content (TPC), total flavonoid content (TFC), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) activity, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) activity. The TPC and TFC, DPPH activity, and ABTS activity values were determined to be 386.7 mg GAE/g and 82.33 mg QE/g, 32.86 %, and 49.4 % respectively. To improve drug delivery, the freeze-dried MO powder was encapsulated within a polymeric carrier, poly(-caprolactone) (PCL). Moreover, the incorporation of montmorillonite (MMT) into the MO-loaded PCL nanoparticles enhanced the encapsulation efficiency and drug loading of MO. Nanoprecipitation was employed as a method to produce the nanoparticles, and the effects of four key parameters were studied: the ratio of aqueous phase volume to organic volume (1.5 – 10), stirring speed (400 rpm – 1200 rpm), mass weightage of MO (1 % -5 %), and mass weightage of MMT (2 % - 5 %). Design Expert was utilized for full factorial analysis to assess the impact of these parameters on encapsulation efficiency and drug loading. The optimal formulation was achieved at the ratio of aqueous phase volume to the organic volume of 1.5, stirring speed of 400 rpm, mass weightage of MO at 1 %, and mass weightage of MMT at 5% The expected encapsulation efficiency is 91.33 % and drug loading is 6.49 %.
      1  23
  • Publication
    Formation of bioresorbable PCL-loaded Moringa Oleifera L./Natural clay functional particles by solvent displacement method for pharmaceutical applications
    (Springer, 2024)
    Monisha Devi
    ;
    Rahimah Othman
    ;
    Mohd Irfan Hatim Mohamed Dzahir
    ;
    Siti Pauliena Mohd Bohari
    Bioresorbable functional particles offer unique advantages based on different synthetic strategies, with the activated moiety may achieve various targeted drug delivery to minimize side effects. Thus, in this study, a highly MO-loaded adsorptive smart-assembled natural clay (montmorillonite, MMT) dispersion onto poly (ε-caprolactone) nanoparticles matrix (hereafter known as MO-loaded MMT/PCL NPs) is formed by solvent displacement method. MMT is selected due to its great drug loading ability due to high specific surface area and grants mucoadhesive properties with tortuous pathway needed for drug delivery across the gastrointestinal barrier. The MO-loaded MMT/PCL NPs are synthesized by self-solvation interaction between the organic phase that composed of dissolved 1 g L−1 PCL, 2–20 wt % of MMT, and 0.6–3.0 g L−1 of MO in acetone and the aqueous phase consisted of 0.2 wt% poly (vinyl alcohol) surfactant solution. The injection rate of organic phase was fixed at 5 mL min−1 with volume ratio aqueous phase to organic phase (Vaq/Vor) between 3–10, and 600–1200 rpm of stirring speed. The inclusion of MMT in polymer was found to improve the entrapment of hydrophilic MO, hence hindering untimely drug leakage. Particle size decreased with increasing the stirring rate and the aqueous-to-organic volumetric ratio as well as the concentration MMT, thus resulting in drug encapsulation efficiency and drug loading up to 30–50 and 5–10%, respectively. The encapsulation of MMT and MO in the NPs was confirmed by X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy.