Prabakaran A/L Poopalan
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Prabakaran A/L Poopalan
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Prabakaran, A/L Poopalan
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Poopalan, P.
Poopalan, Prabakaran A.L.
Poopalan, Prabakaran
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Scopus Author ID
7003686974

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Aptasensing nucleocapsid protein on nanodiamond assembled gold interdigitated electrodes for impedimetric SARS-CoV-2 infectious disease assessment

2022-02-01 , Ramanathan S. , Subash Chandra Bose Gopinath , Ismail Z.H. , Mohd Khairuddin Md Arshad , Prabakaran A/L Poopalan

In an aim of developing portable biosensor for SARS-CoV-2 pandemic, which facilitates the point-of-care aptasensing, a strategy using 10 μm gap-sized gold interdigitated electrode (AuIDE) is presented. The silane-modified AuIDE surface was deposited with ∼20 nm diamond and enhanced the detection of SARS-CoV-2 nucleocapsid protein (NCP). The characteristics of chemically modified diamond were evidenced by structural analyses, revealing the cubic crystalline nature at (220) and (111) planes as observed by XRD. XPS analysis denotes a strong interaction of carbon element, composed ∼95% as seen in EDS analysis. The C–C, C[dbnd]C, C[dbnd]O, C[dbnd]N functional groups were well-refuted from XPS spectra of carbon and oxygen elements in diamond. The interrelation between elements through FTIR analysis indicates major intrinsic bondings at 2687-2031 cm−1. The aptasensing was evaluated through electrochemical impedance spectroscopy measurements, using NCP spiked human serum. With a good selectivity the lower detection limit was evidenced as 0.389 fM, at a linear detection range from 1 fM to 100 pM. The stability, and reusability of the aptasensor were demonstrated, showing ∼30% and ∼33% loss of active state, respectively, after ∼11 days. The detection of NCP was evaluated by comparing anti-NCP aptamer and antibody as the bioprobes. The determination coefficients of R2 = 0.9759 and R2 = 0.9772 were obtained for aptamer- and antibody-based sensing, respectively. Moreover, the genuine interaction of NCP aptamer and protein was validated by enzyme linked apta-sorbent assay. The aptasensing strategy proposed with AuIDE/diamond enhanced sensing platform is highly recommended for early diagnosis of SARS-CoV-2 infection.

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Effect of Laser Ablation on Light Output in LED

2020-06-16 , Chandran H. , Prabakaran A/L Poopalan

Surface roughening is a technique used to modify the light extraction efficiency (LEE) from a LED die. UV laser ablation was used to roughen the backside surface of LED dies by creating pore like structures which would enhance the light output. Measurements of light output before and after laser ablation were taken and modifications of the light output were analysed. The ablating source used was a 248nm pulse focused laser.

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Analysis of an Electrically Induced Optical Waveguide in a c-axis Barium Titanate Thin Film

2021-12-01 , Arif Mawardi Ismail , Prabakaran A/L Poopalan , Nurjuliana Juhari , Mohd. Azarulsani Md. Azidin

In this paper, we report our analysis of an electrically generated optical waveguide in a c-axis barium titanate (BTO) thin film. The waveguide consists of a BTO thin film which is sandwiched between two electrodes. The thin film forms a waveguide when a voltage difference is applied across the electrodes. It is found that the formed waveguide supports both TE and TM modes, with TM modes more tightly confined within the waveguide than TE modes. The possibility to turn the waveguide on and off simply by turning the electric field on and off may prove useful for optical switching.

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