Prabakaran A/L Poopalan
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Prabakaran A/L Poopalan
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Prabakaran, A/L Poopalan
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Poopalan, P.
Poopalan, Prabakaran A.L.
Poopalan, Prabakaran
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7003686974

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Surface charge transduction enhancement on nano-silica and - Alumina integrated planar electrode for hybrid DNA determination

2021-06-01 , Ramanathan S. , Prabakaran A/L Poopalan , Subash Chandra Bose Gopinath , Mohd Khairuddin Md Arshad , Anbu P. , Lakshmipriya T. , Salimi M.N. , Pandian K.

This study represents the surface charge transduction, an efficient and inexpensive biosensor with modifications by silica-alumina entities and determination of gene sequence hybridization. The sensing surface was made by the planar aluminium interdigitated electrode on silicon substrate. Silica and alumina nanoparticles were engineered on the planar transducer surface and the device sensitivity was investigated. The morphology of silica and alumina particles was characterized through the high-resolution election microscopic analyses and revealed the spherical shaped nanoscale sizes at the range of 45–100 nm. The elemental compositions of silica and alumina nanomaterial were affirmed through energy disperse spectroscopy as prominent peaks of Si, Al and O were observed. Selected area electron diffraction analysis of silica and alumina justified their crystalline and amorphous nature, respectively. XRD analysis revealed the expending cristobalite state of silica crystal and γ-alumina for planar electrode surface enhancement. Fourier transform infrared spectroscopy peak observed at 1094 cm−1 revealed the asymmetric stretching of silica nanoparticles whereas the projecting peak observed at 806 cm−1. Additionally, Al–O stretch and Al–O–Al bending modes were justified with the peaks at 585 and 825 cm−1, respectively. Band gap values of silica and alumina computed were 6.75 eV and 3.20 eV, respectively. The results of DNA probe immobilization and complementation have affirmed that silica modified transducer shows the lowest detection at 10 aM whereas alumina modified transducer displayed insignificant current signal and failed to detect DNA hybridization. To investigate the effect of silica entity and its nanocomposite in detecting DNA hybridization, aluminosilicate nanocomposite was deposited on transducer and attained highly sensitive gene detection. Based on the coefficient regression value, aluminosilicate nanocomposite modified planar transducer has shown good device sensitivity (R2 = 0.96) in contrast to silica and alumina entities.

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Multidimensional (0D-3D) nanostructures for lung cancer biomarker analysis: Comprehensive assessment on current diagnostics

2019-09-15 , Ramanathan S. , Subash Chandra Bose Gopinath , Mohd Khairuddin Md Arshad , Prabakaran A/L Poopalan

The pragmatic outcome of a lung cancer diagnosis is closely interrelated in reducing the number of fatal death caused by the world's top cancerous disease. Regardless of the advancement made in understanding lung tumor, and its multimodal treatment, in general the percentage of survival remain low. Late diagnosis of a cancerous cell in patients is the major hurdle for the above circumstances. In the new era of a lung cancer diagnosis with low cost, portable and non-invasive clinical sampling, nanotechnology is at its inflection point where current researches focus on the implementation of biosensor conjugated nanomaterials for the generation of the ideal sensing. The present review encloses the superiority of nanomaterials from zero to three-dimensional nanostructures in its discrete and nanocomposites nanotopography on sensing lung cancer biomarkers. Recent researches conducted on definitive nanomaterials and nanocomposites at multiple dimension with distinctive physiochemical property were focused to subside the cases associated with lung cancer through the development of novel biosensors. The hurdles encountered in the recent research and future preference with prognostic clinical lung cancer diagnosis using multidimensional nanomaterials and its composites are presented.

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Nanostructured aluminosilicate from fly ash: Potential approach in waste utilization for industrial and medical applications

2020-04-20 , Ramanathan S. , Subash Chandra Bose Gopinath , Mohd Khairuddin Md Arshad , Prabakaran A/L Poopalan

Fly ash is found as a significant solid waste released from power plants to the atmosphere, but its qualitative and quantitative consumptions for the sustainability are ambiguous. The main issues aroused with the disposal of fly ash are the requirement of a large land area for landfills, cause toxicity and pollution to the soil and groundwater due to the accumulation of heavy metals. Although fly ash is highly recommended for soil amelioration and cement manufacturing, the ultimate usage of the solid waste causes unsatisfactory effect to the ground system and cementitious product, respectively. Apart from direct utilization and disposal of fly ash, it has been well reported in literature for the synthesis of nanosized particles due to its enrichment in silica, kaolin, iron, and alumina. With this regard, aluminosilicates have been acknowledged as one of the prospective nanocomposites synthesized from fly ash. It has proven that naturally occurring geopolymerization of fly ash under alkaline medium results is in the formation of aluminosilicates. As such, synthetic aluminosilicates were highly encouraged to extract from fly ash in large scale due to their excellent physiochemical properties and applications. This overview intends to fill-up the knowledge gap through critically reviewing about fly ash waste for the synthesis of aluminosilicate nanocomposite. The applications of fly ash derived aluminosilicates in industries such as wastewater treatment, agriculture system and as antioxidants are gleaned. Besides the heavy industrial potential, this review encompasses the prospective alternative consumption of fly ash for the production of nanostructured aluminosilicates and their comprehensive assessment in medical applications, especially in drug carrier and drug delivery systems, bone engineering, biosensors, hemodialysis, and intestinal therapeutics.

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Coherent staking of ultrashort laser pulses in coherent external Fabry-Pérot cavity

2020-01-08 , Tan Chan Sin , Mohamad Halim Abd. Wahid , Prabakaran A/L Poopalan

The ultrashort laser pulses (USP) output from a coherent external Fabry-Pérot cavity (CEFPC) comprising a group delay dispersion (GDD) balanced ultrafast Bragg reflector and a negative-dispersion double-chirped mirror is investigated. As each of the input USP is coherently overlapped with each intracavity USP inside the CEFPC, an increasing USP output amplitude is gradually built up with time, until a steady-state condition is achieved. Analytical results manifest the multiplication factor (MF) or the ratio of output to input pulse repetition rate of the CEFPC equal to unity lead to the generation of continuous, timing-jitter-free, delayed amplitude at an identical repetition rate USP output. Besides, the output intensity pulse train settling time is directly proportional to the finesse of CEFPC.

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Gigahertz repetition rate ultrashort laser pulses from coherent external Fabry-Pérot cavity

2020-01-08 , Chan, Tian Seng , Mohamad Halim Abd. Wahid , Prabakaran A/L Poopalan

Transient analysis of ultrashort laser pulses (USP) output from a coherent external Fabry-Pérot cavity (CEFPC) comprising a group delay dispersion (GDD) balanced ultrafast Bragg reflector and a negative dispersion double-chirped mirror for sub-terahertz repetition rate generation is investigated. Analytical results manifest a low multiplication factor (MF) of the CEFPC with value equal to any non-integer, real number greater than unity (NIRNGU) could lead to the amplitude varying, transient timing-jitter, but at very high constant repetition rate (frep-o-Constant) USP output pulse train. For the configuration - (MF) TaeFP = TaUSP-in, where MF is a NZRNGU, the MF is not a factor which usually describes the relationship between the frep-o and frep-i, but rather a factor which determines the correlation of USPs TUSP-in and TeFP. Besides, this mentioned configuration is proven to be more easily to generate a CW, high frep-o USP train (>10GHz) at steady-state, compared to the conventional configuration with MF equal to a non-zero positive integer, which requires a much shorter external cavity length to generate a similar high frep-o USP train.

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Alkalinized extraction of silica-aluminium nanocomposite from traditional Chinese joss paper: Optical characterizations

2020-03-01 , Ramanathan S. , Subash Chandra Bose Gopinath , Mohd Khairuddin Md Arshad , Prabakaran A/L Poopalan , Anbu P. , Lakshmipriya T. , Lee C.G.

The Chinese traditional joss paper has been recycled and silica and aluminium nanocomposite production is reported in the current research, using an alkalinization procedure. Characterization of silica and aluminium nanocomposite extracted was performed using field-emission transmission electron microscope (FETEM), field-emission scanning electron microscope (FESEM), UV–visible spectroscopy, high-power optical microscopy (HPM) and 3D nano profiler, indicates the size, shape and particle distribution, eventually reveals the purity of silica and aluminium nanocomposite synthesized. The silica-aluminium nanocrystal synthesized from joss paper waste was found to be ~15 nm size range under FETEM analysis and FESEM analysis revealed the uniform spherical shape. The energy disperse spectroscopy (EDX) data attained from FESEM analysis affirmed the synthesis of silica-aluminium nanocomposite with greater purity since the ratio of silicon to aluminium observed in EDX spectra was 13.24 to 7.96. HPM indicated the size of agglomerated aluminosilicate is 36.74 μm whereas 3D nano profiler has proven that the height of nanocrystal synthesized from joss paper waste is 234.37 μm. Band gap value of 3.84 eV, calculated using UV–vis absorbance readings further affirmed the size of nanocomposite which is in good agreement with presented results.

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