Nurul Izni Rusli
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Nurul Izni Rusli
Official Name
Nurul Izni, Rusli
Alternative Name
Rusli, Nurul Izni
Rusli, N. I.
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Scopus Author ID
24725647900
Researcher ID
AAU-9676-2021

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  • Publication
    Miniaturized Electrochemical Device for In-Situ Monitoring of Glucose, Lactate, Dissolved Oxygen, PH, and Temperature in Yeast Culture
    ( 2021-06-20)
    Nurul Izni Rusli
    ;
    Espinar P.L.
    ;
    Ceyssens F.
    ;
    Taurino I.
    ;
    Kraft M.
    This paper presents the integration on a single chip of multiple electrochemical sensors based on amperometric and potentiometric techniques, as well as of a physical sensor. The prototype comprises six sensors for in-situ monitoring of important parameters of a bioprocess; glucose, lactate, pH, cell density, dissolved oxygen, and temperature. All sensor elements have been calibrated and showed acceptable detection performance. We also demonstrate a preliminary experiment for in-situ monitoring in a yeast culture to better understand the response of the proposed microsensors towards yeast fermentations application.
      1
  • Publication
    Multi-Sensor Chip for Monitoring Key Parameters in Bioprocesses
    ( 2021-09-15)
    Nurul Izni Rusli
    ;
    Vincentini I.P.
    ;
    Ceyssens F.
    ;
    Kraft M.
    This paper presents a feasibility study on the integration of multiple biosensors based on amperometric, potentiometric, and impedimetric detection techniques, as well as physical sensors on a single chip. The sensor chip comprises six sensors for in-situ monitoring of important process parameters in a bioprocess: glucose, lactate, pH, cell density, dissolved oxygen concentration, and temperature. The wafer-level parallel fabrication process of multiple microsensors on a single substrate involves four relatively simple processes. The fabricated enzyme sensors were tested with a linear working range up to a concentration of 10 mM for the glucose and lactate sensors and show a fast response time of 20 s. The integrated pH sensor was governed by a near-Nernstian equation with a sensitivity of 60.8 ± 2.4 mV/pH. Cell density, dissolved oxygen, and temperature sensor were also electrically tested. Results obtained from experimental measurements can be considered a promising step towards the realization of a real-time and parallel in-situ measurement platform for bioprocesses.
      2