Adibah Izzati Daud
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Preferred name
Adibah Izzati Daud
Official Name
Adibah Izzati, Daud
Alternative Name
Daud, Adibah Izzati
Main Affiliation
Scopus Author ID
55764818200
Researcher ID
O-5684-2016

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  • Publication
    FT-IR, NMR and X-ray crystallography dataset for newly synthesized alkoxy-chalcone featuring (E)-1-(4-ethylphenyl)-3-(4-(heptyloxy) phenyl)prop‑2-en-1-one
    ( 2020-08-01)
    Khairul W.M.
    ;
    Adibah Izzati Daud
    ;
    Augustine E.
    ;
    Arshad S.
    ;
    Razak I.A.
    Chalcone derivative featuring (E)-1-(4-ethylphenyl)-3-(4-(heptyloxy) phenyl) prop‑2-en-1-one (4EPC) has been successfully synthesized through base-catalyzed Claisen-Schmidt condensation reaction between an aromatic aldehyde and aromatic ketones in alcoholic media under room temperature condition. The synthesized compound was characterized by FT-IR, 1D NMR, and single-crystal X-ray diffraction studies. The compound crystallized in monoclinic space group C2/c. Recently, this synthesized compound attracted considerable interest in its unique characteristic to be used in various applications such as organic light - emitting diode (OLED), organic solar cells, and molecular gas sensor.
  • Publication
    Synthesis and Characterisation of Fused-Aromatic Chalcone as Potential Materials for Detection of Copper (II) Ion
    ( 2023-06-09)
    Adibah Izzati Daud
    ;
    Kamaruzzaman N.S.
    ;
    Khairul W.M.
    Fused-aromatic chalcone derivative (Ch1) featuring donor-π-acceptor system has been synthesized via Claisen-Schmidt reaction between 9-acethylantracene and nitro benzaldehyde in a one-pot reaction system. The synthesised compound has been elucidated using selected spectroscopic and analytical technique such as Fourier-Transform Infrared (FT-IR) spectroscopy,1H and13C Nuclear Magnetic Resonance, Thermogravimetric analysis (TGA) and CHNS elemental analysis. The response of Ch1 molecule towards the detection of copper (ii) ion (Cu2+) has been investigated via the differences in UV-Vis spectra before and upon interaction with Cu2+ ion. In addition, the theoretical simulation was implemented to investigate the relationship between experimental and theoretical finding in term of interaction distance (Å) and the interaction energy (kJ/mol) occurred between the Ch1 and Cu2+ ion. The obtained results indicated that Ch1 from chalcone derivative offered promising potential as ionophore for the detection of Cu2+ ion.
  • Publication
    Exploitation on the organic semiconductors nitro ethynylated-thiourea molecular framework as efficient sensing materials in the detection of carbon dioxide (CO2) by electron donating groups (EDGs) alteration
    ( 2021-10-01)
    Adibah Izzati Daud
    ;
    Khairul W.M.
    ;
    Wahid K.A.A.
    Organic semiconductors of nitro ethynylated-thiourea derivatives of D-π-A (1a-1d) with different donating groups were studied as active materials in the sensing layer, to evaluate their role in enhancing the sensing response (%) towards carbon dioxide (CO2) at ambient temperature. The fabricated 1a-1d on interdigitated electrodes (IDEs) indicate a significant increase in sensing response after exposure to CO2 (10–1000 mg/L) in relative humidity 65–70% RH. The reaction occurs between CO2 gas and water vapour in the designated environment produced two different ions of carbamates and bicarbonates. The increment in the resistivity values of 1a-1d is accredited to the interaction occurred between 1a-1d and the bicarbonate ion at the amide-carbonyl (NH-C[dbnd]O) reactive site. The role of difference donating groups anchored to the molecular framework of ethynylated-thioureas is to stabilize the electron conjugation and fluctuation in the molecular system of D-π-A. The highest sensing response (%) is attributed to 1c with strong activating electron donor group (15.99%−38.57%). 1a and 1b bearing moderate activating electron donor groups possess moderate sensing response towards CO2 (14.05%−36.15%), while 1d contains weak activating electron donor group exhibited the lowest sensing response of 7.82%−24.91%. All the synthesised compounds exhibited moderate response (τres) within 60 s and recovery (τrec) time 180 s significantly for absorption and desorption of CO2. Additionally, the theoretical mechanistic approach to the detection of CO2 was calculated via computational calculation at B3LYP/6-31G (d, p) level of theory to address the correlation between experimental and theoretical approach.
  • Publication
    Effect of pH on functional, gas sensing and antimicrobial properties of bio-nanocomposite gelatin film for food packaging application
    ( 2021-09-01)
    Azizun N.N.
    ;
    Khairul W.M.
    ;
    Adibah Izzati Daud
    ;
    Sarbon N.M.
    A bio-nanocomposite film is a polymer blend with nanofiller dispersed in a biopolymer matrix. The aim of this study is to investigate the functional, gas sensing and antimicrobial properties of bio-nanocomposite films incorporated with chicken skin gelatin/ tapioca starch/zinc oxide at different pH levels (pH 4, 6, 7 and 8). Bio-nanocomposite films were prepared using a casting technique followed by the characterization of their functional, gas sensing and antimicrobial properties. Film formulations with pH at different levels showed increased thickness, colour and water vapour permeability (WVP) (p < 0.05). In addition, the increase of pH in films in chicken skin gelatin bio-nanocomposite films increased the tensile strength (TS), while decreasing the elongation at break (EAB). The highest response for ammonia gas in chicken skin gelatin bio-nanocomposite films was obtained at pH 7, with quick response time (τres) within 10 s. The inhibition zone of Staphylococcus aureus in chicken skin gelatin bio-nanocomposite films increased with increasing pH levels. Overall, chicken skin gelatin bio-nanocomposite films with a pH level of 8 were found to have the optimal formulation, with the highest values in thickness, and TS, with the lowest values for WVP and EAB. In conclusion, bio-nanocomposite chicken skin gelatin films with an alkaline pH are a superior packaging material.
  • Publication
    Structural study of a novel acetylide-thiourea derivative and its evaluation as a detector of benzene
    ( 2017-07-05)
    Wan Mohd Khairul Wan Mohamed Zin
    ;
    Adibah Izzati Daud
    ;
    Noor Azura Mohd Hanifaah
    ;
    Suhana Arshad
    ;
    Ibrahim Abdul Razak
    ;
    Hafiza Mohamed Zuki
    ;
    Mauricio F. Erben
    The new derivative 1-hexanoyl-3-(4-p-tolylethynyl-phenyl)-thiourea (APHX) was synthesised by the addition reaction between 4[4-aminophenyl] ethynyltoluene and hexanoyl isothiocyanate in acetone. The acetylide group was incorporated by using Sonogashira cross-coupling reaction allowing for the preparation of acetylide-thiourea compound. APHX was then elucidated via single crystal X-ray crystallography analysis, spectroscopic and elemental analysis by Fourier Transform Infrared (FT-IR) spectroscopy, 1H and 13C Nuclear Magnetic Resonance (NMR), UV–visible analysis, CHNS-elemental analysis. APHX was also evaluated theoretically via density functional theory (DFT) approach. APHX was fabricated onto glass substrate via drop-cast technique prior to act as optical thin-film and its performance as volatile organic compounds (VOCs) sensor was investigated through the difference in UV–vis profile before and after exposure towards benzene. Preliminary findings revealed that APHX showed interaction towards benzene with about 48% sensitivity. According to thermogravimetric studies, APHX showed good thermal stability, without decomposition up to ca. 190 °C. Whilst, crystal structure of APHX consists in a nearly planar acylthiourea moiety with the C[dbnd]O and C[dbnd]S bonds utilizing trans position, favoring by an intramolecular N[sbnd]H⋯O[dbnd]C hydrogen bonds. The alkyl chain is oriented 90° with respect to acylthiourea group. The phenyls group in the 1-methyl-4-(phenylethynyl)benzene moieties are mutually planar and slightly twisted with respect to the acylthiourea plane. Centrosymmetric dimers generated by intermolecular N[sbnd]H⋯S[dbnd]C and C[sbnd]H⋯S[dbnd]C hydrogen bonds forming R22 (8) and R21(6) motifs are present in the crystals. The interaction between APHX with benzene has been modelled and calculated using density functional theory (DFT) via Gaussian 09 software package and the preferred sites of binding are located at the acylthiourea group.
  • Publication
    Synthesis, molecular docking and biological activity evaluation of alkoxy substituted chalcone derivatives: Potential apoptosis inducing agent on mcf-7 cells
    ( 2021-09-01)
    Khairul W.M.
    ;
    Hashim F.
    ;
    Mohammed M.
    ;
    Shah N.S.M.N.
    ;
    Johari S.A.T.T.
    ;
    Rahamathullah R.
    ;
    Adibah Izzati Daud
    ;
    Ma N.L.
    Introduction: In this contribution, a series of alkoxy substituted chalcones were successfully designed, synthesized, spectroscopically characterized and evaluated for their cytotoxicity potential in inhibiting the growth of MCF-7 cells. Objective: In order to investigate the influence between electron density in conjugated π-systems and biological activities, different withdrawing substituents, namely Nitro (NO2), Cyano (C≡N) and trifluoromethyl (CF3) were introduced in the chalcone-based molecular system. Methods: All the derivatives were then tested on MCF-7 cell line using the fluorescence microscopy-based cytotoxicity analyses. Results: The preliminary findings showed that both –NO2 and –CF3 substituents revealed their potential to inhibit the growth of MCF-7 with IC50 values of 14.75 and 13.75 µg/ml, respectively. In addition, the morphological changes of MCF-7 cells were observed in response to alkoxy substituted chalcone treatment through an induction of apoptosis pathway with cell blebbing, phosphatidylserine exposure and autophagic activity with acidification of lysosomal structure. Intermolecular interaction based on in silico investigation on nitro, trifluoromethyl and cyano based chalcones exhibited several types of interactions with tumor necrosis factor receptor (PDB: 1EXT) protein and high hydrogen bond in the molecule-receptor interaction have given significant impact towards their toxicity on MCF-7 cells. Conclusion: Significantly, these types of chalcones exhibited ideal and high potential to be further developed as anti-cancer agents.
  • Publication
    In vitro antimicrobial activities, molecular docking and density functional theory (DFT) evaluation of natural product-based vanillin derivatives featuring halogenated azo dyes
    ( 2023-01-01)
    Ngaini Z.
    ;
    Hissam M.A.
    ;
    Mortadza N.A.
    ;
    Abd Halim A.N.
    ;
    Adibah Izzati Daud
    Chemical modification of active scaffolds from natural products has gained interest in pharmaceutical industries. Nevertheless, the metabolites extraction is time-consuming while the lead is frequently mismatched with the receptor. Here, the diazo coupling approach was introduced to generate a series of vanillin derivatives featuring halogenated azo dyes (1a-h). The vanillin derivatives showed effective inhibition of S. aureus (7-9 mm) and E. coli (7-8 mm) compared to the parent vanillin, while 1b had the highest inhibition zone (9 mm) against S. aureus comparable to the reference ampicillin. The presence of N = N, C = O, -OH, -OCH3 and halogens established strategic binding interactions with the receptor. The potential vanillin-azo as an antimicrobial drug was supported by in silico docking with penicillin-binding proteins and DFT (using Gaussian 09) with binding affinity −7.5 kcal/mol and energy gap (Egap) 3.77 eV, respectively. This study represents a significant advancement in drug discovery for effective antibiotics with excellent properties.
  • Publication
    Silica–silver core–shell nanoparticles incorporated with cellulose filter paper as an effective colorimetric probe for mercury ion detection in aqueous media: Experimental and computational evaluations
    ( 2023-05-01)
    Azmi A.A.
    ;
    Adibah Izzati Daud
    ;
    Khairul W.M.
    ;
    Hamzah S.
    ;
    Wan Mohd Khalik W.M.A.
    ;
    Hanis Hayati Hairom N.
    This study investigates the facile and rapid detection of mercury ions using silica–silver core–shell nanoparticles (SiO2–AgNPs) incorporating a paper-based colorimetric sensor strip. A strong surface plasmon resonance peak at λ = 430 nm was observed for the resultant SiO2–AgNPs. The attachment of the AgNPs to the surface of SiO2 and the deposition of the AgNPs on the paper strip were confirmed using an electron microscope. The sensing of the SiO2–AgNPs toward the mercuric ion (Hg2+) in an aqueous solution indicated a rapid response in terms of a color change from yellowish-brown to colorless with a response time of 5–10 s. The prepared SiO2–AgNPs deposited on the paper strip exhibited high selectivity toward Hg2+ compared with other metal ions. The limit of detection for this assay was 1.13 nM, with an excellent correlation value of R2 = 0.9936. In addition, the complexation mode of the SiO2–AgNPs with Hg2+ was also elucidated via theoretical calculations using the density functional theory approach. This approach also provides insight into the complexation structure in terms of the electronic alteration of the SiO2–AgNPs prior to and following their interaction with Hg2+. Overall, the study demonstrates that SiO2–AgNP-based sensor materials can be utilized for the selective recognition of Hg2+ in aqueous solutions.
  • Publication
    A Dual Approach on Experimental, Theoretical Insight of Structural Elucidation, Hirshfeld Surface Analysis, Optical and Electrochemical Properties of Acyl Thiourea-Ethynyl Hybrid Derivatives
    ( 2022-09-01)
    Adibah Izzati Daud
    ;
    Khairul W.M.
    ;
    Arshad S.
    ;
    Razak I.A.
    ;
    González D.L.N.
    ;
    Erben M.F.
    Hybrid moieties of ethynylated-thiourea, Th1 and Th2 have been synthesised via the addition reaction between ethynyl derivatives and 4-tert-butylbenzoyl isothiocyanate in acetone, and were characterised by selected spectroscopic methods (i.e., 1H and 13C NMR, UV–visible, FT-IR) and elemental analysis. Thermogravimetric analysis indicated that Th1 and Th2 were relatively stable up to ca. 210 °C. Single-crystal X-ray diffraction was used to identify the crystal structure of Th2 in which the centre of 1-acyl thiourea moiety (-C(O)NHC(S)NH) exhibits S conformation. The Hirshfeld surface analysis has allowed visualizing the crystal packing, which is characterised by the prolonged intermolecular N–H⋯O = C and N–H⋯S = C hydrogen-bonding interactions within Th2 molecule. Electrochemical data of both compounds correspondingly exhibit irreversible redox potential processes. Besides, frontier molecular orbitals and Natural Bond Orbital population analysis were computed at the B3LYP/6-31G (d, p) level of approximation, suggesting strong delocalization of the electronic density through a conjugated π-system involving the ethynyl-phenyl and thiourea groups. Graphical Abstract: Figure of molecular structure for acyl thiourea-ethynyl derivative. Two derivatives of acyl thiourea-ethynyl were synthesised and characterised by selected spectroscopic methods such as 1H and 13C NMR, UV-visible, FT-IR, elemental, thermal, electrochemical, X-ray diffraction, and density functional theory (DFT) calculation for molecular orbitals and natural bond orbital population analysis. [Figure not available: see fulltext.]
  • Publication
    Halochromic smart film: a gelatin-based pH-sensitive film embedded with anthocyanin from roselle (Hibiscus sabdariffa) extracts for potential food spoilage indicator application
    (John Wiley and Sons Inc, 2025-03)
    Najma Farhaten Latiff
    ;
    Nur Fazlin Sulaiman
    ;
    Mannur Ismail Shaik
    ;
    Nizaha Juhaida Mohamad
    ;
    Wan Mohd Khairul
    ;
    Adibah Izzati Daud
    ;
    Norizah Mhd Sarbon
    This study developed and characterized a pH-sensitive gelatin-based film incorporated with anthocyanin from roselle extracts (Hibiscus sabdariffa) at varying concentrations (0%–15%). The addition of anthocyanins significantly influenced the film's properties, reducing tensile strength from 1.5 to 1.1 MPa while increasing elongation at break from 312% to 416%. Water vapor permeability also increased with anthocyanin concentration, ranging from 1.02 to 1.47 × 10−⁸ g·m−¹·s−¹·Pa−¹. The film displayed a distinct color change from red to yellow-green across pH 3–10 and when exposed to ammonia gas, highlighting its potential for real-time detection of volatile basic compounds. Fourier transform infrared analysis revealed molecular interactions between gelatin and anthocyanins, with increasing roselle extract concentrations as it showed enhanced amide A, I, II, and III functional groups. Scanning electron micrographs revealed increased surface roughness and microstructural changes with anthocyanin addition. These findings demonstrate the potential of 15% roselle anthocyanin–gelatin films as eco-friendly, pH-sensitive smart packaging materials for food applications.