Molybdenum disulfide (MoS<inf>2</inf>)/gold nanoparticles (AuNPs)-based field-effect transistor for C-reactive protein detection: Early diagnosis of cardiovascular disease

C-reactive protein (C-RP), a biomarker for inflammatory validation associated with cardiovascular disease (CVD). Major infection or severe trauma trigger the activation of this protein in the patient’s blood. In this paper, the conventional field-effect transistor (FET) is fabricated and followed by direct deposition method of molybdenum disulfide (MoS2) nanosheets. The deposition of MoS2 nanosheets with the conjugation of 30 nm gold nanoparticles on the 100 active channel shows the good response of electrical signals for C-RP detection. Analysis of the MoS2 and AuNPs was well-supported by atomic force microscopy, scanning electron microscopy, UV-Vis spectroscopy, and high-power microscopy. Finally, the detection limit of 100 fg/mL was attained.