Now showing 1 - 2 of 2
  • Publication
    Surface plasmon resonance sensor sensitivity enhancement using gold-dielectric material
    (Universiti Malaysia Perlis (UniMAP), 2017-07)
    S. Fouad
    ;
    Naseer Sabri
    ;
    ;
    There has been increasing interest in the field of surface plasmon resonance sensing technology according to its advantages such as the small amount of sensing samples required, freedom of electromagnetic interference and greater sensitivity. This research investigates the using of a thin layer of dielectric material such as Barium Titanate (BaTio3) over the Gold (Au) layer for enhancing the sensitivity of the surface plasmon resonance sensor based phase interrogation technique. BaTio3 is adopted due to its excellent dielectric properties such as high dielectric constant and low dielectric loss. Numerical results have demonstrated that the surface plasmon resonance sensor with utilizing a thin layer of the BaTio3 layer (5nm) over a fixed Au layer thickness of (50nm) exhibited a high sensitivity of (250 degree/RIU) among other thickness values of BaTio3. Contrarily, the comparison of the surface plasmon resonance sensor without utilizing BaTio3 layer provides (160 degree/RIU) for fixed Au layer thickness (50nm). Hence, using of 5mm thin layer of BaTio3 over 50nm of Au layer within surface Plasmon layer yield higher sensitivity of 250 (degree/RIU).
      4  16
  • Publication
    Evaluation of GO and rGO on breast cancer cell line (MCF7) and normal breast cell line (MCF10a) for cell viability and electrical response
    (Universiti Malaysia Perlis (UniMAP), 2018-12)
    Siti S. Mat Isa
    ;
    N. S. Mazlan
    ;
    ;
    L. F. A. Talip
    ;
    Rafeezul Mohamed
    ;
    Graphene based materials become a phenomenal in various applications including biomedical devices due to their excellent properties. Their effects towards certain diseases were broadly studies and presented. However, the work has been performed was only limited to the graphene oxide (GO) and its biocompatibility only. In this work, the interaction of GO and reduced graphene oxide (rGO) on breast cancer cell (MCF7) and normal breast cell (MCF10a) was investigated specifically on the cell viability, cell mortality and current-voltage (IV) relationship. Graphene oxide and rGO at the concentration of 100μg/mL were prepared by chemical methods. The morphology and quality of both materials were characterized using AFM and Raman Spectroscopy. The cells were treated for 24 hours and the effects of these materials on the viability and mortality of the cell were observed. The interaction between graphene-based materials and both cells significantly impact the current-voltage (IV) characteristics. The results show that GO and rGO did not affect the cell viability but only small percentage different was obtained on cell mortality. It also observed that the resistance of cell treated with rGO decreased with time for MCF7 and vice versa for MCF10a. While for GO, the resistance of cell increased with time for MCF7 and vice versa for MCF10a. These clear patterns of these interactions lead to a good input for biosensor fabrication which was aimed to be used as the early diagnosis cancer stem cell point of care (POC) device.
      4  15